Sabrina Simoes, PhD

Academic Appointments

  • Assistant Professor of Neurological Sciences (in Neurology and in the Taub Institute) at CUMC

Dr. Sabrina Simoes is a cellular neurobiologist who has spent her career studying endosomal trafficking in normal and pathological conditions. Research in her lab focus on understanding the mechanisms underlying the pathogenesis of Alzheimer’s disease (AD), with special emphasis on endo-lysosomal dysfunction. Dr. Simoes received her PhD in cell biology from the Institute Curie and University Paris Descartes (Paris, France). During her undergraduate and graduate training in the laboratory of Dr. Graca Raposo - a world leader in the exosome/endosome field—she developed a strong interest in intracellular trafficking. Her early studies focused on how ubiquitous endosomal machineries are explored by prion proteins for their sorting into exosomes and concomitant spread in vitro, as well as for the maturation of endosomal compartments. In 2011, she joined Columbia University laboratory of Dr. Scott Small, where she continued to pursue her studies on endosomal trafficking in the context of neurodegeneration. Having recently been promoted to Assistant Professor of Neurological Sciences, in Neurology and the Taub Institute, Dr. Simoes’ research aims at identifying and developing new biomarkers for Alzheimer’s disease and other neurodegenerative disorders. Her translational approach combines in vitro (cultured neurons and other cell lines), in vivo (transgenic mice) model systems, as well as human biospecimens (plasma and cerebral spinal fluid) from healthy controls and patients. In her mouse-to-human studies, Dr. Simoes employs a wide range of techniques including light and electron microscopies, as well as state of the art biomarker platforms such as “Single Molecule Array” (Simoa), Mesoscale (MSD) Multi-Array, and nanoparticles tracking systems.

Departmental Appointments

  • Department of Neurology
    Division of Aging and Dementia

Education and Training

  • MS, Cell Biology, Curie Institute (France)
  • PhD, Cell Biology, Curie Institute (France)

NIH Grants

  • TARGETING RETROMER DYSFUNCTION: A CONVERGENT MECHANISM IN FAMILIAL AND SPORADIC PD (Private)

    Sep 1 2014 - Jun 30 2019

    TARGETING RETROMER DYSFUNCTION: A CONVERGENT MECHANISM IN FAMILIAL AND SPORADIC PD (Private)

    Sep 1 2014 - Dec 31 2018

    TARGETING RETROMER DYSFUNCTION: A CONVERGENT MECHANISM IN FAMILIAL AND SPORADIC PD (Private)

    Sep 1 2014 - Aug 31 2017

    FMRI AND MOUSE MODELS OF ALZHEIMER S DISEASE (Federal Gov)

    Jul 15 2010 - Jun 30 2016

    VALIDATING A RETROMER STABILIZING COMPOUND FOR ALZHEIMERS DISEASE THERAPEUTICS (Private)

    Jan 14 2013 - Jan 13 2015

    HISTONE ACETYLATION AND COGNITIVE AGING (Federal Gov)

    Sep 1 2009 - Aug 31 2014

    ENHANCEMENT OF COGNITION (Federal Gov)

    Jun 1 2011 - May 31 2014

    UNDERSTANDING THE POTENTIAL ROLE OF CF WITH REGARD TO BRAIN FUNCTION AND COGNITION (Private)

    Apr 16 2009 - May 15 2014

    ADULT NEUROGENESIS: BRIDGING THE GAP BETWEEIN MACRO AND MICRO-NEUROSCIENCES (Private)

    Sep 14 2007 - Mar 14 2013