Laboratories

Cognitive Neuroscience of Aging Laboratory - Yaakov Stern 

www.columbia.edu/cu/cna
This lab explores cognitive changes throughout aging and their neural basis, with a strong focus on state-of-the-art cognitive approaches and multi-modal imaging.  We deal with two main themes: understanding cognitive aging and understanding individual differences in susceptibility to aging and Alzheimer's disease.  We are also conducting other studies, including a study of the natural history of Alzheimer’s disease, and cognitive intervention trials in healthy elders that focus on both exercise and cognitive stimulation

 

Disparities in Cognitive Aging and Dementia Research Laboratory - Jennifer Manly

Disparities in cognitive aging and risk for Alzheimer’s disease and related dementias are well-established, but the mechanisms that maintain these disparities are not well-understood. The Disparities in Cognitive Aging and Dementia Research Laboratory aims to identify causal relationships between sociocultural, economic, educational, linguistic, biological, and genetic factors and cognitive function and cognitive decline among racially and ethnically diverse older adults. This is accomplished through careful examination of brain health and neuropsychological function among diverse individuals, and assessment of potential mechanisms throughout the lifecourse using longitudinal data from prospectively followed cohorts. One focus of this work is to identify factors that promote cognitive resilience in populations with early life disadvantage. The goal of this work is to identify potential interventions for promoting brain health among diverse people, and reducing disparities in cognitive aging and dementia.

 

Laboratory of Aging and Translational Neuropsychology - Adam Brickman

Our laboratory integrates neuropsychology, neuroimaging, basic science, and epidemiology to understand the determinants and cognitive consequences of aging and neurodegenerative disease.  With a special focus on structural neuroimaging, we have been particularly interested in the role of white matter and cerebrovascular factors in cognitive aging in general and in Alzheimer’s disease specifically, in addition to age and disease-associated changes in brain structure.

 

Subjective Cognition and Metacognition in Aging and Dementia - Stephanie Cosentino

The overarching goal of this lab is to examine the cognitive and metacognitive profiles of age-related neurodegenerative diseases, particularly Alzheimer's disease and Frontotemporal dementia (FTD), and to clarify their neuroanatomic substrates. Within this broad context, recent work in the lab has sought to characterize the multitude of factors that contribute to subjective cognition across the spectrum of healthy to pathological aging, and to identify the consequences of disordered subjective cognition.
 

Brain Networks Laboratory (BNet) - Chris Habeck & Yunglin Gazes

www.columbia.edu/cu/bnet
Our lab features both methodological and applied neuroimaging analysis using multivariate and multimodal machine-learning techniques. A major focus of the applied and developed tools is the practical utility for clinical and basic cognitive neuroscience. Multivariate decompositions (like principal/independent component analysis) are used in conjunction with simple machine learning tools (naïve Bayes, k-nearest-neighbor classifier, linear and quadratic discriminant classifier, support vector machines) and resampling techniques (permutation test, bootstrap test) for statistical inference. 


Multiple Sclerosis Cognitive Neuroscience Laboratory - Victoria Leavitt

Our laboratory’s primary focus is identifying risk and protective factors for cognitive impairment in multiple sclerosis (MS). One important impediment to the development of effective treatment/rehabilitation of cognitive impairment in MS is the paucity of known neural substrates for cognitive impairment and decline. Using multimodal neuroimaging methods (e.g., structural and functional MRI), the MSCNL aims to identify novel treatment targets and sensitive outcome variables for use in clinical trials, an essential first step for developing effective treatments of cognitive impairment.


Healthy Aging and Dementia Prevention Laboratory - Yian Gu

The primary focus of this lab is to understand how lifestyle factors can help promote healthy aging and prevent dementia and other neurodegenerative diseases. More specifically, the lab aims to identify risk and protective factors for aging and dementia, including but not limited to, diet and nutrition, physical activities, leisure activities, sleep, and air pollution. Ongoing studies in the lab also aim to identify the underlying biological mechanisms, as well as explore the role of lifestyle factors in cognitive aging and dementia among diverse populations and younger adults.