Guy M. McKhann, II, MD

Academic Appointments

  • Associate Professor of Neurological Surgery at CUMC
Guy M. McKhann, II, MD

Dr. McKhann graduated Phi Beta Kappa and Magna Cum Laude from Duke University, with Research Honors for his investigations into brain tumor immunobiology. He attended Yale School of Medicine where he was AOA, Cum Laude, a Farr Scholar, and one of five recipients of the medical school’s highest thesis award. Dr. McKhann trained in Neurological Surgery at the University of Washington, as well as Atkinson Morley’s Hospital in Wimbledon, England.

Dr. McKhann combines clinical skill and compassionate care to maximize patient outcomes. He treats patients with a variety of brain conditions including Brain Tumors, Epilepsy, Movement Disorders, Adult Hydrocephalus, Chiari Malformations, Cavernous Malformations, Trigeminal Neuralgia, and Neurotrauma. His areas of particular technical expertise include microneurosurgery, computer guided stereotactic neuronavigation, intraoperative awake brain mapping, neuroendoscopy, minimally invasive brain surgery, gamma knife radiosurgery, deep brain stimulation, and cerebrospinal fluid shunting.

Dr. McKhann also works as a translational neuroscientist, running a laboratory that investigates epileptic development and treatment. In addition he helps direct a multidisciplinary team that studies the mechanisms of brain plasticity, recovery, and repair. His basic and clinical research has been funded by the National Institutes of Health, the American Association of Neurological Surgeons, the Klingenstein Foundation, the Charles A. Dana Foundation, the New York Academy of Medicine, Parents Against Childhood Epilepsy, and the Irving Center for Clinical Research.

Departmental Appointments

  • Department of Neurological Surgery

Education and Training

  • Yale University School of Medicine
  • Residency: University of Washington Medical Center
  • Fellowship: University of Washington Medical Center

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center

Lab Locations

  • CUMC/Neurological Institute of New York

    710 West 168th Street
    413
    New York, NY 10032
    Phone:
    (212) 305-0052
    Fax:
    (212) 305-3629

Research Interests

  • Adult hydrocephalus
  • Astrocyte function in epilepsy
  • Brain organization of language and motor function

NIH Grants

  • MECHANISMSOF RAPID, FLEXIBLE COGNITIVE CONTROL IN HUMAN PREFRONTAL CORTEX (Federal Gov)

    Sep 30 2018 - Jul 31 2019

    ELUCIDATING THE CAUSES OF REGIONAL ELECTROPHYSIOLOGIC DISCREPANCIES IN FOCAL EPILEPSY: DRAWING LINES IN THE SAND WITH THE ICTAL ONSET ZONE (Private)

    Mar 23 2018 - Mar 22 2019

    SEIZURE LOCALIZATION IN HUMANS: THE EFFECT OF INHIBITORY SUROUND ON THE EEG (Federal Gov)

    Sep 1 2013 - Jun 30 2018

    SEIZURE LOCALIZATION IN HUMANS: THE EFFECT OF INHIBITORY SUROUND ON THE EEG (Federal Gov)

    Sep 1 2013 - Jun 30 2018

    TARGETING THE MTOR PATHWAY IN GILOMA-ASSOCIATED EPILEPSY IN MICE AND HUMANS (Private)

    Sep 1 2015 - Aug 31 2017

    RADIOSURGERY VS LOBECTOMY FOR TEMPORAL LOBE EPILEPSY: PHASE 3 CLINICAL TRIAL (Federal Gov)

    Jun 1 2014 - May 31 2015

    RADIOSURGERY VS. LOBECTOMY FOR TEMPORAL LOBE EPILEPSY: PHASE 3 CLINICAL TRIAL (Federal Gov)

    Jun 1 2011 - May 31 2012

    ABERRANT ASTROCYTIC CONTROL OF NEURONAL EXCITABILITY IN TUBE ROUS SCLEROSIS: A POTENTIAL THERAPEUTIC TARGET IN TSC EPILEP (Private)

    Jul 1 2008 - Jun 30 2011

    HHMI FELLOWSHIP--REACTIVE GLIOSIS IN A RAT MODEL OF TEMPORAL LOBE EPILEPSY--CELLULAR LINEAGE AND ELECTROPHYSIOLOGIC... (Private)

    Jul 1 2007 - Jun 30 2008

    PLASTICITY IN THE MATURE BRAIN: PATTERNS OF CORTICAL REORGANIZATION FOLLOWING BRAIN LESION REMOVAL (Private)

    May 1 2001 - Jan 1 2008