The Network for Excellence in Neuroscience Clinical Trials, or NeuroNEXT, was created to conduct studies of treatments for neurological diseases through partnerships with academia, private foundations, and industry. The network is designed to expand the National Institute of Neurological Disorders and Stroke's (NINDS) capability to test promising new therapies, increase the efficiency of clinical trials before embarking on larger studies, and respond quickly as new opportunities arise to test promising treatments for people with neurological disorders. The NeuroNEXT program aims to:
- Provide a robust, standardized, and accessible infrastructure to facilitate rapid development and implementation of protocols in neurological disorders affecting adult and/or pediatric populations.
- The network includes multiple Clinical Sites, one Clinical Coordinating Center (CCC) and one Data Coordinating Center (DCC).
- Support scientifically sound, possibly biomarker-informed, Phase II clinical trials that provide data for clear go/no-go decisions.
- Energize and mobilize federal, industry, foundations and patient advocacy partners by leveraging existing relationships between NINDS and NeuroNEXT to organize high impact Phase II clinical trials for neurological disorders.
- Expand the pool of experienced clinical investigators and research staff who are prepared to be leaders of multicenter clinical research trials.
- Principal Investigator: Karen Marder, MD, MPH (Columbia)
- Principal Investigator: Claudia A. Chiriboga, MD, MPH (Columbia)
- Principal Investigator: Claire Henchcliffe, MD, DPhil (Weill Cornell)
- Project Manager: Joyce Ann Moran, CCRC, Phone: (212) 305-8367
- CUMC and Weill Cornell Medical College in the News
- Recent NeuroNEXT Publications
- NN101 Recruitment and Retention Manuscript
- NN101 Primary Paper, "Natural History of Infantile-Onset Spinal Muscular Atrophy"
- Editorial accompanying NN101 SMA primary results publication
- NN102 Paper, "Design, rationale, and baseline characteristics of the randomized double-blind phase II clinical trial of ibudilast in progressive multiple sclerosis"
- NN104 Paper, "Selecting patients for intraarterial therapy in the context of a clinical trial for neuroprotection"
- NN102 Primary Results published in New England Journal of Medicine
Current NeuroNEXT studies:
Join the CUMC-WCMC NeuroNEXT Network
Columbia-Weill Cornell is establishing a network of affiliate neurologists/neurosurgeons and organizations to participate in NeuroNEXT studies. As a NeuroNEXT affiliate, you will receive occasional e-mails about upcoming clinical trials and events. To be placed on our e-mail list, please contact Joyce Ann Moran at firstname.lastname@example.org.
How to Submit a Proposal?
Develop an idea and call one of our team members. We will be happy to guide you through the process to complete the Clinical Study Concept Synopsis. For more information, visit www.neuronext.org/researchers
NeuroNEXT Fellowship Program
The NeuroNEXT Fellowship program is an initiative to provide research experiences and career enhancement opportunities to early-stage investigators. This program is geared to develop future clinical trialists.
o The NeuroNEXT Fellowship program is an initiative to provide research experiences and career enhancement opportunities to early-stage investigators. This program is geared to develop future clinical trialists.
o The goal of this program is to prepare the individual to work towards obtaining a K award or to obtain foundation or other independent research support by the end of their NeuroNEXT fellowship.
o Awardees will be funded by NINDS for @20,000 (approximately 10% effort) of salary, inclusive of fringe.
o The NeuroNEXT Fellowship for the 2018-2019 grant year was awarded to Nora Vanegas-Arroyave, MD.
o 2019-2020 NeuroNEXT Fellowship Program Application Materials: Due February 28, 2019. Please send completed application packet to Joyce Ann Moran at email@example.com
§ 1-page personal statement
§ A letter from the Division Chief agreeing to protected time
§ A templated synopsis of the planned research proposal, if available
- A webinar is a presentation by the PI to discuss his protocol that is getting ready for submission and to get feedback for improvement. Please check back for more information
- A Brainstorming Session is a forum for specialists to discuss research priorities and to develop new NeuroNEXT proposal ideas. Please check back for more information.
- If you would like to be notified of upcoming NeuroNEXT events, please email Joyce Ann Moran at firstname.lastname@example.org.