Aging
- Identifying beneficial and detrimental factors in cognition during aging/studies of healthy elderly (Biomarkers–WHICAP): Richard Mayeux, MD
- Long Life Family Study (LLFS): Richard Mayeux, MD; Lawrence Honig, MD, PhD
- Imaging hippocampal subregions in aging (exercise study, MARS study): Scott Small, MD
- Biomarkers in plasma and CSF: Lawrence Honig, MD, PhD
Alzheimer's Disease (AD)
Identifying genetic and epigenetic risk factors for the development of AD in multiethnic populations
- Identifying genes affecting AD risk (biomarkers-WHICAP, LOAD, ADGC, IGAP, ADSP projects): Richard Mayeux, MD
- Examining the role of protein processing as risk factor for AD: Scott Small, MD
- Studying role of telomeres in aging and dementia (Biomarkers-WHICAP,CNSHS, LLFS projects): Lawrence Honig, MD, PhD
- Identifying risk profiles of AD that predict rate of progression of AD
- Role of inflammatory, cardiovascular risk factors on the course of AD: Richard Mayeux, MD
- Imaging hippocampal sub-regions in AD: Scott Small, MD
- Role of dietary risk factors on progression of AD: Nikolaos Scarmeas, MD, MS
- Role of dental microbes in the progression of AD: James Noble, MD
- Clinical, imaging, and biomarkers in AD (ADRC): Lawrence Honig, MD,PhD
Clinical trials in AD, mild cognitive impairment, and pre-symptomatic individuals
- A4 trial, BACE inhibitor: Karen Bell, MD
- Solanezumab trials, DIAN-TU, crenezumab, MTX, Lu, EVP: Lawrence Honig, MD, PhD
- MARS flavonol: Scott Small, MD
Parkinson's Disease (PD)
- Identifying risk profiles of PD that predict rate of progression of PD
- Multicenter cohort of early (<50 and late onset PD): Karen Marder, MD, MPH
- Identifying the individuals at high risk for PD
- PPMI, Core PD, Penetrance: Karen Marder, MD, MPH
- Identifying genetic risk factors for the development of PD and DLB in multiethnic populations
- CORE PD: Karen Marder, MD, MPH
- ADRC and DLB grant: Lawrence Honig, MD, PhD
Huntington’s disease (HD)
- Natural History of HD
- Enroll HD: Karen Marder, MD, MPH
- Individuals at high risk for HD
- PREDICT HD: Karen Marder, MD, MPH
- Clinical Trials for HD
- PBT-2, TEVA, 2CARE, Creatine: Karen Marder, MD, MPH
Frontotemporal Dementia (FTD)
- Genes and Risk factors in FTD: Edward Huey, MD
- Clinical trials for FTD
- Tolcapone: Edward Huey, MD; Lawrence Honig, MD, PhD