Aging

• Identifying beneficial and detrimental factors in cognition during aging/studies of healthy elderly (Biomarkers–WHICAP): Richard Mayeux, MD
• Long Life Family Study (LLFS): Richard Mayeux, MD; Lawrence Honig, MD, PhD
• Imaging hippocampal subregions in aging (exercise study, MARS study): Scott Small, MD
• Biomarkers in plasma and CSF: Lawrence Honig, MD, PhD

Alzheimer's Disease (AD)

Identifying genetic and epigenetic risk factors for the development of AD in multiethnic populations

• Identifying genes affecting AD risk (biomarkers-WHICAP, LOAD, ADGC, IGAP, ADSP projects): Richard Mayeux, MD
• Examining the role of protein processing as risk factor for AD: Scott Small, MD
• Studying role of telomeres in aging and dementia (Biomarkers-WHICAP,CNSHS, LLFS projects): Lawrence Honig, MD, PhD
• Identifying risk profiles of AD that predict rate of progression of AD
• Role of inflammatory, cardiovascular risk factors on the course of AD: Richard Mayeux, MD
• Imaging hippocampal sub-regions in AD: Scott Small, MD
• Role of dietary risk factors on progression of AD: Nikolaos Scarmeas, MD, MS
• Role of dental microbes in the progression of AD: James Noble, MD
• Clinical, imaging, and biomarkers in AD (ADRC): Lawrence Honig, MD,PhD

Clinical trials in AD, mild cognitive impairment, and pre-symptomatic individuals

• A4 trial, BACE inhibitor: Karen Bell, MD
• Solanezumab trials, DIAN-TU, crenezumab, MTX, Lu, EVP: Lawrence Honig, MD, PhD
• MARS flavonol: Scott Small, MD

Parkinson's Disease (PD)

• Identifying risk profiles of PD that predict rate of progression of PD
  • Multicenter cohort of early (<50 and late onset PD): Karen Marder, MD, MPH
• Identifying the individuals at high risk for PD
  • PPMI, Core PD, Penetrance: Karen Marder, MD, MPH
• Identifying genetic risk factors for the development of PD and DLB in multiethnic populations
  • CORE PD: Karen Marder, MD, MPH
  • ADRC and DLB grant: Lawrence Honig, MD, PhD

Huntington’s disease (HD)

• Natural History of HD
  • Enroll HD: Karen Marder, MD, MPH
• Individuals at high risk for HD
  • PREDICT HD: Karen Marder, MD, MPH
• Clinical Trials for HD
  • PBT-2, TEVA, 2CARE, Creatine: Karen Marder, MD, MPH

Frontotemporal Dementia (FTD)

• Genes and Risk factors in FTD: Edward Huey, MD​
• Clinical trials for FTD
  • Tolcapone: Edward Huey, MD; Lawrence Honig, MD, PhD