Tristan T. Sands, MD, PhD

  • Assistant Professor of Neurology at CUMC
Tristan T. Sands, MD, PhD

Tristan Sands, MD, PhD is an assistant professor of neurology at Columbia University Irving Medical Center (CUIMC) in the Division of Child Neurology and the Institute for Genomic Medicine (IGM).

Dr. Sands completed his child neurology residency at the University of California, San Francisco under the mentorship of Dr. Roberta Cilio and epilepsy and clinical neurophysiology fellowships at Columbia University Irving Medical Center under the tutelage of Dr. Cigdem Akman and Dr. James Riviello.

Dr. Sands is a pediatric and neonatal neurologist and epileptologist with clinical and research experience in seizures, epilepsies and developmental and epileptic encephalopathies resulting from genetic causes. His research into treatments for genetic epilepsies has demonstrated that benign neonatal seizures caused by mutation of the KCNQ2 and KCNQ3 genes show a universal response to carbamazepine and that early use of carbamazepine reduces the length of hospital admission for these newborns. He has described how de novo KCNQ3 variants are responsible for a novel form of neurodevelopmental disability.

Dr. Sands will be evaluating epilepsy patients with putative genetic etiologies in a new Translational Medicine Clinic for the Genetic Epilepsies and conducting research on precision medicine for the genetic epilepsies with the IGM.

Boards and other certifications:

ABPN – Epilepsy; Clinical Neurophysiology; Neurology with Special Qualification in Child Neurology

Additional clinical expertise:

Genetic causes of epilepsy, including but not limited to, variants in KCNQ2, KCNQ3, SCN1A, SCN2A, SCN8A, KCNT1, STXBP1, CHD2, SYNGAP1, CDKL5, PCDH19, KCNH1, DEPDC5, PIGA, GNAO1, UBE3A, DYRK1A, PRRT2, ARX, NBEA, DNM1, TSC1, TSC2, KANSL1, GRIN2A, ZEB2, MECP2, MEF2C, SMC1A, etc.

Departmental Appointments

  • Department of Neurology
    Division of Child Neurology

Board Certifications

  • Neurology with Special Qualification in Child Neurology

Areas of Expertise

  • Neurogenetics
  • Epilepsy with Myoclonic-Atonic Seizures (Myoclonic-Astatic Epilepsy, Doose syndrome)
  • West syndrome
  • Ohtahara syndrome and Early Myoclonic Encephalopathy
  • Benign Neonatal Epilepsy
  • Genetic Epilepsies
  • Neonatal Neurology
  • Pediatric Epilepsy
  • Pediatric Neurology
  • Epileptic Encephalopathies
  • Neonatal Epilepsy
  • Neonatal and Infantile Epileptic Encephalopathies
  • Aicardi syndrome
  • Dravet syndrome
  • Electrical Status Epilepticus during Sleep (ESES) and the Landau–Kleffner syndrome
  • Epileptic Seizures
  • Lennox-Gastaut syndrome

Education & Training

  • MD, Columbia University College of Physicians and Surgeons
  • Residency: University of California San Francisco Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Locations

  • CUMC/Neurological Institute of New York

    710 West 168th Street
    New York, NY 10032
    For new and current patient appointments, call:
    (212) 342-6867
    Fax:
    (212) 342-6865
  • CUMC/Harkness Pavilion

    180 Fort Washington Avenue
    Floor: 5
    New York, NY 10032
    For new and current patient appointments, call:
    (212) 342-6867
    Fax:
    (212) 342-6865
  • ColumbiaDoctors West 86th Street

    21 West 86th Street
    New York, NY 10024
    For new and current patient appointments, call:
    (212) 342-6867
    Fax:
    (212) 342-6865

Provider Affiliations

  • NewYork-Presbyterian/Columbia
  • NewYork-Presbyterian/Morgan Stanley Children's Hospital

Insurance Programs

Please contact the provider's office directly to verify that your particular insurance is accepted.

  • Aetna [EPO, HMO, Medicare Managed Care, NY Signature, NYP Employee Plan, POS, PPO, Signature Administrators, Student Health]
  • Affinity [Essential Plan, Medicaid Managed Care]
  • Amida Care [Special Needs Plan]
  • Cigna [EPO, Great West, HMO, POS, PPO]
  • Emblem/GHI [Medicare Managed Care, PPO]
  • Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]
  • Empire Blue Cross Blue Shield [Blue Access (Exchange), EPO, Gatekeeper (Exchange), HMO, Medicare Managed Care, Pathway (Exchange), POS, PPO]
  • Empire Blue Cross Blue Shield HealthPlus [Child/Family Health Plus, Essential Plan, Medicaid Managed Care]
  • Fidelis Care [Child/Family Health Plus, Medicaid Managed Care, Medicare Managed Care]
  • Healthfirst [Child/Family Health Plus, Leaf (Exchange), Medicaid Managed Care, Medicare Managed Care]
  • Local 1199 [Local 1199]
  • MagnaCare [MagnaCare]
  • Multiplan [Multiplan]
  • MVP Health Care [Child/Family Health Plus, Essential Plan, HMO, Medicaid Managed Care]
  • Oxford Health Plans [Freedom, Liberty, Medicare Managed Care]
  • UnitedHealthcare [Columbia University Employee Plan, Compass (Exchange), HMO, Medicaid (Community Plan), Medicare Managed Care, POS, PPO]
  • VNSNY CHOICE [Medicare Managed Care, SelectHealth, Special Needs Plan]
  • WellCare [Medicaid Managed Care, Medicare Managed Care]

This provider sees pediatric patients

This provider accepts new patients

Appointment Phone Number: (646) 426-3876

Teaching Responsibilities

Lectures in the Basic and Clinical Neuroscience Course, CUMC, 2017-

Neurology Rotation Preceptor, CUMC, 2017-

Neuroanatomy Teaching Assistant, UCSF, 2013-2015

3rd Year Medical Student Neurological Examination Preceptor, UCSF, 2013-2015

1st Year Medical Student Neurological Examination Instructor and Evaluator, UCSF, 2013-2015

Honors & Awards

American Epilepsy Society Young Investigator Award, 2017
Exceptional Physician (P.R.I.D.E.) Award, UCSF, 2012
 

Publications

Original Research

  • Autism and developmental disability caused by KCNQ3 gain-of-function variants. Ann Neurol. 2019 Jun 8. Sands TT, Miceli F, Lesca G, Beck AE, Sadleir LG, Arrington DK, Schönewolf-Greulich B, Moutton S, Lauritano A, Nappi P, Soldovieri MV, Scheffer IE, Mefford HC, Stong N, Heinzen EL, Goldstein DB, Grijalvo Perez A, Kossoff EH, Stocco A, Sullivan JA, Shashi V, Gerard B, Francannet C, Bisgaard AM, Tümer Z, Willems M, Rivier F, Vitobello A, Thakkar K, Rajan DS, Barkovich AJ, Weckhuysen S, Cooper EC, Taglialatela M, Cilio MR.

  • The Epilepsy Genetics Initiative: Systematic reanalysis of diagnostic exomes increases yield. Epilepsia. 2019 May;60(5):797-806. Epilepsy Genetics Initiative.

  • Long-term safety, tolerability, and efficacy of cannabidiol in children with refractory epilepsy: results from an expanded access program in the US. CNS Drugs. 2019 Jan; 33(1):47-60. Sands TT, Oldham MS, Caminha Nunes E, Tilton N, Cilio MR.

  • The ClinGen Epilepsy Gene Curation Expert Panel-Bridging the divide between clinical domain knowledge and formal gene curation criteria. Hum Mutat. 2018 Nov;39(11):1476-1484. Helbig I, Riggs ER, Barry CA, Klein KM, Dyment D, Thaxton C, Sadikovic B, Sands TT, Wagnon JL, Liaquat K, Cilio MR, Mirzaa G, Park K, Axeen E, Butler E, Bardakjian TM, Striano P, Poduri A, Siegert RK, Grant AR, Helbig KL, Mefford HC.

  • NBEA: Developmental disease gene with early generalized epilepsy phenotypes. Ann Neurol. 2018 Sep 30. Mulhern MS, Stumpel C, Stong N, Brunner HG, Bier L, Lippa N, Riviello J, Rouhl RPW, Kempers M, Pfundt R, Stegmann APA, Kukolich MK, Telegrafi A, Lehman A; CAUSES study, Lopez-Rangel E, Houcinat N, Barth M, den Hollander N, Hoffer MJV, Weckhuysen S; EuroEPINOMICS-RES-MAE working group, Roovers J, Djemie T, Barca D, Ceulemans B, Craiu D, Lemke JR, Korff C, Mefford HC, Meyers CT, Siegler Z, Hiatt SM, Cooper GM, Bebin EM, Snijders Blok L, Veenstra-Knol HE, Baugh EH, Brilstra EH, Volker-Touw CML, van Binsbergen E, Revah-Politi A, Pereira E, McBrian D, Pacault M, Isidor B, Le Caignec C, Gilbert-Dussardier B, Bilan F, Heinzen EL, Goldstein DB, Stevens SJC, Sands TT.

  • Refining the phenotype associated with GNB1 mutations: Clinical data on 18 newly identified patients and review of the literature. Am J Med Genet A. 2018 Sep 8. Hemati P, Revah-Politi A, Bassan H, Petrovski S, Bilancia CG, Ramsey K, Griffin NG, Bier L, Cho MT, Rosello M, Lynch SA, Colombo S, Weber A, Haug M, Heinzen EL, Sands TT, Narayanan V, Primiano M, Aggarwal VS, Millan F, Sattler-Holtrop SG, Caro-Llopis A, Pillar N, Baker J, Freedman R, Kroes HY, Sacharow S, Stong N, Lapunzina P, Schneider MC, Mendelsohn NJ, Singleton A, Loik Ramey V, Wou K, Kuzminsky A, Monfort S, Weiss M, Doyle S, Iglesias A, Martinez F, Mckenzie F, Orellana C, van Gassen KLI, Palomares M, Bazak L, Lee A, Bircher A, Basel-Vanagaite L, Hafström M, Houge G; C4RCD Research Group; DDD study, Goldstein DB, Anyane-Yeboa K.

  • Lack of response to quinidine in KCNT1-related neonatal epilepsy. Epilepsia. 2018 Sep 4. Numis AL, Nair U, Datta AN, Sands TT, Oldham MS, Patel A, Li M, Gazina E, Petrou S, Cilio MR.

  • De novo variants in the alternative exon 5 of SCN8A cause epileptic encephalopathy. Genet Med. 2018 Feb;20(2):275-281. Epilepsy Genetics Initiative.

  • Rapid and safe response to low dose carbamazepine in neonatal epilepsy. Epilepsia. 2016 Dec; 57(12):2019-2030. Sands TT, Balestri M, Bellini G, Mulkey SB, Danhaive O, Bakken EH, Taglialatela M, Oldham MS, Vigevano F, Holmes GL, Cilio MR.

  • Focal seizures in children with anti-NMDA receptor antibody encephalitis. Epilepsy Res. 2015 May; 112:31-6. Sands TT, Nash K, Tong S, Sullivan J.

Invited Presentations

  •  “Genetic landscape of epilepsy” in Child Neurology: Genetic and Metabolic Testing in Pediatric Epilepsy. American Academy of Neurology. Philadephia, May 2019.

  • “The genetics of epilepsy” 6th Human Genetics in NYC Conference, New York, Oct 2018.

  • “Advances in neurogenetics: epilepsy” in Advances in Neurogenetics. American Academy of Neurology. Los Angeles, April 2018.

  • “The genetics of epilepsy” and “Neonatal seizures”  7th Pedia Dubai International Pediatric Conference, Dubai, April 2018.

  • “The genetics of epilepsy” in Managing Epilpesy: Many Routes on the Journey to Full Control. New York, Sept 2017.

  • “The phenotypic spectrum of KCNQ–associated neonatal epilepsies” in Neonatal Genetic Epilepsies: A Personalized Medicine Approach. Invited Science Session, Pediatric Academic Societies. San Francisco, May 2017.

Review Articles

  • Rasmussen Encephalitis: An Update. Semin Neurol. 2019. In Press.

  • Neonatal Epilepsies: Clinical management. Semin Fetal Neonatal Med. 2018 Jan 31. Cornet MC, Sands TT, Cilio MR.

  • Genetic Testing in Pediatric Epilepsy. Curr Neurol Neurosci Rep. 2017 May. 17(5):45. Sands TT & Choi H.

  • Recent Advances in Neonatal Seizures. Curr Neurol Neurosci Rep. 2016 Oct. 16(10):92. Sands TT & McDonough TL.

Book Chapters

  • “Seizures and Epilepsies in Neonates and Children” in Merritt’s Neurology, 14th Ed. In Press. Sands TT & Cilio MR.

  • “Neonatal Seizures” in Workbook in Practical Neonatology, 6th Ed. In Press. Sands TT & Akman CI.

  • "Neonatal Onset Epilepsies" in Neurology: Neonatology: Questions and Controversies, 3rd Ed. Sept 17, 2018. Cilio MR & Sands TT.

  • "Genetics of Epilepsy" in Swaiman's Pediatric Neurology, 6th Ed. Jun 15, 2017. Cilio MR & Sands TT.

  • “NMDA Receptor Antibody Encephalitis” in Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics: A Case-Based Clinical Guide, 1st Ed. Oct 27, 2017. Sands TT, Kedzierski K, Makhani N.

Abstracts & Platforms

  • A novel variant in the S4 voltage-sensor of KCNQ3 implicated in Benign Familial Neonatal Epilepsy. Abstract. International Kv7 Channels Symposium. Naples, September 2019. Sands TT, Miceli F, Stong, N, Goldstein DB, Mandel A, Cilio MR, Heinzen EL, Taglialatela M, Cooper EC.

  • Pediatric longitudinal cortical thickness pipeline maps atrophy in Rasmussen Encephalitis. Abstract. Human Brain Mapping. Rome, June 2019. Provenzano F, Sands TT.

  • Autism with benzodiazepine-responsive electrical status epilepticus in sleep (ESES) caused by KCNQ3 gain-of-function variants. Platform presentation. 3rd Dianalund International Conference on Epilepsy. Denmark, June 2018. Sands TT, Miceli F, Lesca G, Beck A, Cimino M, Stong N, Heinzen EL, Goldstein DB, Lowenstein DB, Weckhuysen S, Cooper EC, Taglialatela M, Cilio MR.

  • Autism with benzodiazepine-responsive electrical status epilepticus in sleep (ESES) caused by KCNQ3 gain-of-function variants. Abstract. American Epilepsy Society. Washington DC, Dec 2017. Sands TT, Miceli F, Lesca G, Beck A, Cimino M, Stong N, Heinzen E, Goldstein DB, Lowenstein DB, Weckhuysen S, Cooper EC, Taglialatela M, Cilio MR.

  • Apneic seizures in neonates. Abstract. American Epilepsy Society. Vancouver, Dec 2016. Sands TT, Oldham MS, Nunes E, Cilio MR.

  • Benign Familial Neonatal Seizures Exquisitely Sensitive to Carbamazepine. Abstract. American Epilepsy Society. Washington DC, Dec 2015. Sands TT, Balestri M, Bellini G, Mulkey SB, Danhaive O, Bakken EH, Taglialatela M, Oldham MS, Vigevano F, Holmes GL, Cilio MR.

For a complete list of publications, please visit PubMed.gov