Columbia Researchers Create New Model of ALS

CUMC Newsroom
February 12, 2016

Mutations in more than 20 genes are known to cause amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, but much of what we know about the disease has been learned from mouse models with mutations in just one gene, SOD1, the first gene linked to ALS.

To help scientists gain a more complete understanding of ALS and how it can be treated, researchers in Columbia’s Motor Neuron Center have created new mouse models based on mutations in a recently discovered ALS gene called FUS. [read more]